Int. J. Environ. Res. Public Health 2009, 6(6), 1744-1759; doi:10.3390/ijerph6061744
Article

Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach

1,* email, 2email, 3email, 4email and 5email
Received: 30 April 2009; Accepted: 27 May 2009 / Published: 3 June 2009
(This article belongs to the Special Issue Smoking and Tobacco Control)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Maternal smoking during pregnancy is a major public health problem that has been associated with numerous short- and long-term adverse health outcomes in offspring. However, characterizing smoking exposure during pregnancy precisely has been rather difficult: self-reported measures of smoking often suffer from recall bias, deliberate misreporting, and selective non-disclosure, while single bioassay measures of nicotine metabolites only reflect recent smoking history and cannot capture the fluctuating and complex patterns of varying exposure of the fetus. Recently, Dukic et al. [1] have proposed a statistical method for combining information from both sources in order to increase the precision of the exposure measurement and power to detect more subtle effects of smoking. In this paper, we extend the Dukic et al. [1] method to incorporate individual variation of the metabolic parameters (such as clearance rates) into the calibration model of smoking exposure during pregnancy. We apply the new method to the Family Health and Development Project (FHDP), a small convenience sample of 96 predominantly working-class white pregnant women oversampled for smoking. We find that, on average, misreporters smoke 7.5 cigarettes more than what they report to smoke, with about one third underreporting by 1.5, one third under-reporting by about 6.5, and one third underreporting by 8.5 cigarettes. Partly due to the limited demographic heterogeneity in the FHDP sample, the results are similar to those obtained by the deterministic calibration model, whose adjustments were slightly lower (by 0.5 cigarettes on average). The new results are also, as expected, less sensitive to assumed values of cotinine half-life.
Keywords: smoking; self-report; bioassay; calibration
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MDPI and ACS Style

Dukic, V.M.; Niessner, M.; Pickett, K.E.; Benowitz, N.L.; Wakschlag, L.S. Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach. Int. J. Environ. Res. Public Health 2009, 6, 1744-1759.

AMA Style

Dukic VM, Niessner M, Pickett KE, Benowitz NL, Wakschlag LS. Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach. International Journal of Environmental Research and Public Health. 2009; 6(6):1744-1759.

Chicago/Turabian Style

Dukic, Vanja M.; Niessner, Marina; Pickett, Kate E.; Benowitz, Neal L.; Wakschlag, Lauren S. 2009. "Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach." Int. J. Environ. Res. Public Health 6, no. 6: 1744-1759.

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