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Int. J. Environ. Res. Public Health 2009, 6(4), 1530-1538; doi:10.3390/ijerph6041530
Article

Real World Study to Evaluate the Effectiveness of Varenicline and Cognitive-Behavioural Interventions for Smoking Cessation

1,*  and 2
1 Smoking Cessation Clinic. Hospital Universitario de Bellvitge. Feixa Llarga s/n 08907 Hospitalet. Barcelona, Spain 2 Smoking Cessation Clinic. Hospital Universitario de Vall d’Hebron. Passeig de la Vall d’Hebron 119-129. 08035 Barcelona, Spain
* Author to whom correspondence should be addressed.
Received: 10 March 2009 / Accepted: 16 April 2009 / Published: 21 April 2009
(This article belongs to the Special Issue Tobacco Smoking and Public Health)
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Abstract

A prospective pragmatic interventional study was conducted to evaluate the effectiveness of varenicline for smoking cessation among a cohort of motivated smokers attending two smoking cessation clinics. Smokers between 18 and 65 years who had smoked 10 or more cigarettes per day were included. All participants received cognitive-behavioural varenicline according to approved dose and prescriptions. Continuous abstinence, validated by exhaled CO levels, was assessed in each control. A total of 264 smokers – 155 males (58.7%) and 109 females (41.3%) – were included. Mean age was 43.7, amount smoked was 23 cigarettes per day and 61.4% had at least one prior attempt to quit. The continuous abstinence rate at end of treatment (12 wks) was 58.3%. Conclusions: varenicline and cognitive-behavioural intervention are effective for smoking cessation with high continuous abstinence rates when are used in a clinical setting.
Keywords: Smoking cessation; varenicline; cognitive-behavioural intervention; continuous abstinence Smoking cessation; varenicline; cognitive-behavioural intervention; continuous abstinence
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ramon, J.M.; Bruguera, E. Real World Study to Evaluate the Effectiveness of Varenicline and Cognitive-Behavioural Interventions for Smoking Cessation. Int. J. Environ. Res. Public Health 2009, 6, 1530-1538.

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