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Reply published on 25 May 2016, see Int. J. Environ. Res. Public Health 2016, 13(6), 533.

Comment of Int. J. Environ. Res. Public Health 2016, 13(3), 246.

Open AccessComment
Int. J. Environ. Res. Public Health 2016, 13(6), 532; doi:10.3390/ijerph13060532

Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health 2016, 13, 246

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Søborg DK-2860, Denmark
Academic Editor: Paul B. Tchounwou
Received: 3 March 2016 / Revised: 3 March 2016 / Accepted: 23 May 2016 / Published: 25 May 2016
View Full-Text   |   Download PDF [242 KB, uploaded 25 May 2016]

Abstract

Profiling the expression levels of genes or proteins in tissues comprising two or more cell types is commonplace in biological sciences. Such analyses present particular challenges, however, for example a potential shift in cellular composition, or ‘cellularity’, between specimens. That is, does an observed change in expression level represent what occurs within individual cells, or does it represent a shift in the ratio of different cell types within the tissue? This commentary attempts to highlight the importance of considering cellularity when interpreting quantitative expression data, using the mammalian testis and a recent study on the effects of phthalate exposure on testis function as an example. View Full-Text
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Svingen, T. Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health 2016, 13, 246. Int. J. Environ. Res. Public Health 2016, 13, 532.

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