Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246
Conflicts of Interest
References
- Svingen, T. Comments on Li et al. Effects of in utero exposure to dicyclohexyl phthalate on rat fetal leydig cells. Int. J. Environ. Res. Public Health, 2016, 13, 246. Int. J. Environ. Res. Public Health 2016, 13. [Google Scholar] [CrossRef] [Green Version]
- Li, X.; Chen, X.; Hu, G.; Li, L.; Su, H.; Wang, Y.; Chen, D.; Zhu, Q.; Li, C.; Li, J.; et al. Effects of in utero exposure to dicyclohexyl phthalate on rat fetal leydig cells. Int. J. Environ. Res. Public Health 2016, 13, 246. [Google Scholar] [CrossRef] [PubMed]
- Shono, T.; Kai, H.; Suita, S.; Nawata, H. Time-specific effects of mono-n-butyl phthalate on the transabdominal descent of the testis in rat fetuses. BJU Int. 2000, 86, 121–125. [Google Scholar] [CrossRef] [PubMed]
- Akingbemi, B.T.; Youker, R.T.; Sottas, C.M.; Ge, R.; Katz, E.; Klinefelter, G.R.; Zirkin, B.R.; Hardy, M.P. Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biol. Reprod. 2001, 65, 1252–1259. [Google Scholar] [PubMed]
- Fisher, J.S.; Macpherson, S.; Marchetti, N.; Sharpe, R.M. Human “testicular dysgenesis syndrome”: A possible model using in-utero exposure of the rat to dibutyl phthalate. Hum. Reprod. 2003, 18, 1383–1394. [Google Scholar] [CrossRef] [PubMed]
- Akingbemi, B.T.; Ge, R.; Klinefelter, G.R.; Zirkin, B.R.; Hardy, M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc. Natl. Acad. Sci. USA 2004, 101, 775–780. [Google Scholar] [CrossRef] [PubMed]
- Mahood, I.K.; Hallmark, N.; McKinnell, C.; Walker, M.; Fisher, J.S.; Sharpe, R.M. Abnormal leydig cell aggregation in the fetal testis of rats exposed to di(n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology 2005, 146, 613–623. [Google Scholar] [CrossRef] [PubMed]
- Borch, J.; Axelstad, M.; Vinggaard, A.M.; Dalgaard, M. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. Toxicol. Lett. 2006, 163, 183–190. [Google Scholar] [CrossRef] [PubMed]
- Mahood, I.K.; McKinnell, C.; Walker, M.; Hallmark, N.; Scott, H.; Fisher, J.S.; Rivas, A.; Hartung, S.; Ivell, R.; Mason, J.I.; et al. Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate. Int. J. Androl. 2006, 29, 148–154. [Google Scholar] [CrossRef] [PubMed]
- Lin, H.; Ge, R.S.; Chen, G.R.; Hu, G.X.; Dong, L.; Lian, Q.Q.; Hardy, D.O.; Sottas, C.M.; Li, X.K.; Hardy, M.P. Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc. Natl. Acad. Sci. USA 2008, 105, 7218–7222. [Google Scholar] [CrossRef] [PubMed]
- Lin, H.; Lian, Q.Q.; Hu, G.X.; Jin, Y.; Zhang, Y.; Hardy, D.O.; Chen, G.R.; Lu, Z.Q.; Sottas, C.M.; Hardy, M.P.; et al. In utero and lactational exposures to diethylhexyl-phthalate affect two populations of leydig cells in male long-evans rats. Biol. Reprod. 2009, 80, 882–888. [Google Scholar] [CrossRef] [PubMed]
- Li, L.; Bu, T.; Su, H.; Chen, Z.; Liang, Y.; Zhang, G.; Zhu, D.; Shan, Y.; Xu, R.; Hu, Y.; et al. In utero exposure to diisononyl phthalate caused testicular dysgenesis of rat fetal testis. Toxicol. Lett. 2014, 232, 466–474. [Google Scholar] [CrossRef] [PubMed]
- Migrenne, S.; Moreau, E.; Pakarinen, P.; Dierich, A.; Merlet, J.; Habert, R.; Racine, C. Mouse testis development and function are differently regulated by follicle-stimulating hormone receptors signaling during fetal and prepubertal life. PLoS ONE 2012, 7, e53257. [Google Scholar] [CrossRef] [PubMed]
- Gray, L.E., Jr.; Wolf, C.; Lambright, C.; Mann, P.; Price, M.; Cooper, R.L.; Ostby, J. Administration of potentially antiandrogenic pesticides (procymidone linuron iprodione chlozolinate pp’-DDE and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate PCB 169 and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health 1999, 15, 94–118. [Google Scholar]
- Mylchreest, E.; Cattley, R.C.; Foster, P.M. Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: An antiandrogenic mechanism? Toxicol. Sci. 1998, 43, 47–60. [Google Scholar] [CrossRef] [PubMed]
- Vasta, V.; Shimizu-Albergine, M.; Beavo, J.A. Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc. Natl. Acad. Sci. USA 2006, 103, 19925–19930. [Google Scholar] [CrossRef] [PubMed]
- Gray, L.E., Jr.; Ostby, J.; Monosson, E.; Kelce, W.R. Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicol. Ind. Health 1999, 15, 48–64. [Google Scholar] [CrossRef] [PubMed]
- Doerks, T.; Copley, R.R.; Schultz, J.; Ponting, C.P.; Bork, P. Systematic identification of novel protein domain families associated with nuclear functions. Genome Res. 2002, 12, 47–56. [Google Scholar] [CrossRef] [PubMed]
- Pandey, A.K.; Li, W.; Yin, X.; Stocco, D.M.; Grammas, P.; Wang, X. Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells. J. Endocrinol. 2010, 204, 67–74. [Google Scholar] [CrossRef] [PubMed]
- Ge, R.S.; Hardy, M.P. Regulation of Leydig cells during pubertal development. In The Leydig Cell in Health and Disease; Payne, A.H., Hardy, M.P., Eds.; Humana Press: Totowa, ON, Canada, 2007; pp. 55–70. [Google Scholar]
- Jiang, M.H.; Cai, B.; Tuo, Y.; Wang, J.; Zang, Z.J.; Tu, X.; Gao, Y.; Su, Z.; Li, W.; Li, G.; et al. Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. Cell Res. 2014, 24, 1466–1485. [Google Scholar] [CrossRef] [PubMed]
- Adham, I.M.; Emmen, J.M.; Engel, W. The role of the testicular factor INSL3 in establishing the gonadal position. Mol. Cell. Endocrinol. 2000, 160, 11–16. [Google Scholar] [CrossRef]
- Zhou, L.; Beattie, M.C.; Lin, C.Y.; Liu, J.; Traore, K.; Papadopoulos, V.; Zirkin, B.R.; Chen, H. Oxidative stress and phthalate-induced down-regulation of steroidogenesis in MA-10 Leydig cells. Reprod. Toxicol. 2013, 42, 95–101. [Google Scholar] [CrossRef] [PubMed]
- Yuan, K.; Zhao, B.; Li, X.W.; Hu, G.X.; Su, Y.; Chu, Y.; Akingbemi, B.T.; Lian, Q.Q.; Ge, R.S. Effects of phthalates on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities in human and rat testes. Chem. Biol. Interact. 2012, 195, 180–188. [Google Scholar] [CrossRef] [PubMed]
- Thompson, C.J.; Ross, S.M.; Hensley, J.; Liu, K.; Heinze, S.C.; Young, S.S.; Gaido, K.W. Differential steroidogenic gene expression in the fetal adrenal gland vs. the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate. Biol. Reprod. 2005, 73, 908–917. [Google Scholar] [CrossRef] [PubMed]
- Welsh, M.; Sharpe, R.M.; Moffat, L.; Atanassova, N.; Saunders, P.T.; Kilter, S.; Bergh, A.; Smith, L.B. Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics. PLoS ONE 2010, 5, e13632. [Google Scholar] [CrossRef] [PubMed]
- Ge, R.S.; Dong, Q.; Sottas, C.M.; Papadopoulos, V.; Zirkin, B.R.; Hardy, M.P. In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development. Proc. Natl. Acad. Sci. USA 2006, 103, 2719–2724. [Google Scholar] [CrossRef] [PubMed]
- Garcia, T.X.; Costa, G.M.; Franca, L.R.; Hofmann, M.C. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod. Toxicol. 2014, 45, 59–70. [Google Scholar] [CrossRef] [PubMed]
- Shan, L.X.; Hardy, M.P. Developmental changes in levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells. Endocrinology 1992, 131, 1107–1114. [Google Scholar] [PubMed]
- Shan, L.X.; Phillips, D.M.; Bardin, C.W.; Hardy, M.P. Differential regulation of steroidogenic enzymes during differentiation optimizes testosterone production by adult rat Leydig cells. Endocrinology 1993, 133, 2277–2283. [Google Scholar] [PubMed]
- Ge, R.S.; Hardy, M.P. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998, 139, 3787–3795. [Google Scholar] [CrossRef] [PubMed]
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Li, X.; Chen, X.; Hu, G.; Li, L.; Su, H.; Wang, Y.; Chen, D.; Zhu, Q.; Li, C.; Li, J.; et al. Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246. Int. J. Environ. Res. Public Health 2016, 13, 533. https://doi.org/10.3390/ijerph13060533
Li X, Chen X, Hu G, Li L, Su H, Wang Y, Chen D, Zhu Q, Li C, Li J, et al. Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246. International Journal of Environmental Research and Public Health. 2016; 13(6):533. https://doi.org/10.3390/ijerph13060533
Chicago/Turabian StyleLi, Xiaoheng, Xiaomin Chen, Guoxin Hu, Linxi Li, Huina Su, Yiyan Wang, Dongxin Chen, Qiqi Zhu, Chao Li, Junwei Li, and et al. 2016. "Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246" International Journal of Environmental Research and Public Health 13, no. 6: 533. https://doi.org/10.3390/ijerph13060533