Next Article in Journal
The Association of Exposure to Point-of-Sale Tobacco Marketing with Quit Attempt and Quit Success: Results from a Prospective Study of Smokers in the United States
Next Article in Special Issue
A Review of Groundwater Arsenic Contamination in Bangladesh: The Millennium Development Goal Era and Beyond
Previous Article in Journal
Diabetes Mellitus, ArterialWall, and Cardiovascular Risk Assessment
Previous Article in Special Issue
Synthesis of Minerals with Iron Oxide and Hydroxide Contents as a Sorption Medium to Remove Arsenic from Water for Human Consumption
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(2), 205; doi:10.3390/ijerph13020205

Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis

Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 29 November 2015 / Accepted: 2 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Arsenic in Drinking Water: Current Perspectives and Future Directions)
View Full-Text   |   Download PDF [3484 KB, uploaded 15 February 2016]   |  

Abstract

Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase (p< 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p< 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p< 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process. View Full-Text
Keywords: arsenic; methylation; meta-analysis; human arsenic; methylation; meta-analysis; human
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shen, H.; Niu, Q.; Xu, M.; Rui, D.; Xu, S.; Feng, G.; Ding, Y.; Li, S.; Jing, M. Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2016, 13, 205.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top