Next Article in Journal
Evaluating Physical and Perceptual Responses to Exergames in Chinese Children
Next Article in Special Issue
Building-Related Symptoms among Office Employees Associated with Indoor Carbon Dioxide and Total Volatile Organic Compounds
Previous Article in Journal
Let It “B”? The Role of Hepatitis B Universal Vaccination among Italian Problematic Drug Users
Previous Article in Special Issue
Exposure to Airborne Particles and Volatile Organic Compounds from Polyurethane Molding, Spray Painting, Lacquering, and Gluing in a Workshop
Article Menu

Export Article

Open AccessReview
Int. J. Environ. Res. Public Health 2015, 12(4), 3993-4017; doi:10.3390/ijerph120403993

Exposure to Indoor Pollutants and Wheeze and Asthma Development during Early Childhood

Florence Nightingale School of Nursing and Midwifery, King's College London, London SE18WA, UK
Department of Thoracic Medicine, Medical School, University of Crete, Heraklion 71414, Greece
MRC-PHE Centre for Environment and Health, NIHR Environmental Hazards Health Protection Research Unit, King's College London, London SE19NH, UK
Author to whom correspondence should be addressed.
Academic Editors: Gary Adamkiewicz and M. Patricia Fabian
Received: 4 February 2015 / Revised: 25 March 2015 / Accepted: 3 April 2015 / Published: 13 April 2015
(This article belongs to the Special Issue Indoor Environmental Quality: Exposures and Occupant Health)
View Full-Text   |   Download PDF [756 KB, uploaded 13 April 2015]   |  


Background: This review aimed to summarize existing epidemiological evidence of the association between quantitative estimates of indoor air pollution with early childhood respiratory disease. Methods: We carried out a systematic literature search of peer-reviewed epidemiological studies undertaken in “westernized” countries that have assessed exposure to indoor pollutants and asthma and wheeze from infancy up to the age of 5. Results: The search, between January 2004 and February 2014 yielded 1840 studies for consideration. Following application of eligibility criteria to titles and abstracts 22 independent studies were deemed relevant for further review. Two additional studies were next identified through examination of the references’ lists of these studies. Of these 24 selected studies, 16 adopted a prospective cohort design and 8 were case-control studies. Fourteen studies assessed exposure to bio-aerosols, 8 studies assessed exposure to specific air chemicals and two studies assessed exposure to bio-aerosols and air chemicals. Furthermore, 11 studies examined the association of exposure with asthma and 16 with wheeze. Findings indicate that existing studies have reported contradictory effects of indoor pollutants levels and occurrence of asthma/wheeze. Conclusion: Additional research to establish causality and evaluate interventions to prevent disease onset is needed. View Full-Text
Keywords: environmental exposures; indoor air pollution; bio-aerosols; respiratory disease; asthma; wheezing; childhood environmental exposures; indoor air pollution; bio-aerosols; respiratory disease; asthma; wheezing; childhood

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Patelarou, E.; Tzanakis, N.; Kelly, F.J. Exposure to Indoor Pollutants and Wheeze and Asthma Development during Early Childhood. Int. J. Environ. Res. Public Health 2015, 12, 3993-4017.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top