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Int. J. Environ. Res. Public Health 2014, 11(7), 7537-7561; doi:10.3390/ijerph110707537

Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior

1
School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada
2
Interdisciplinary School of Health Sciences, University of Ottawa, 25 University Private, Thompson Hall, Ottawa, ON K1N 6X1, Canada
*
Author to whom correspondence should be addressed.
Received: 11 June 2014 / Revised: 10 July 2014 / Accepted: 14 July 2014 / Published: 22 July 2014
(This article belongs to the Special Issue Endocrine Disruptors and Human Health)
View Full-Text   |   Download PDF [229 KB, uploaded 22 July 2014]

Abstract

Bisphenol A (BPA) is a synthetic compound used in the production of many polycarbonate plastics and epoxy resins. It is one of the most widely produced chemicals in the world today and is found in most canned goods, plastics, and even household dust. Exposure to BPA is almost universal: most people have measurable amounts of BPA in both urine and serum. BPA is similar in structure to estradiol and can bind to multiple targets both inside and outside the nucleus, in effect acting as an endocrine disruptor. Research on BPA exposure has accelerated in the past decade with findings suggesting that perinatal exposure to BPA can negatively impact both male and female reproduction, create alterations in behavior, and act as a carcinogen. BPA can have both short term and long term effects with the latter typically occurring through epigenetic mechanisms such as DNA methylation. This review will draw on both human and animal studies in an attempt to synthesize the literature and examine the effects of BPA exposure on reproduction, behavior, and carcinogenesis with a focus on the potential epigenetic mechanisms by which it acts. View Full-Text
Keywords: bisphenol A; endocrine disruptor; reproduction; epigenetics; toxicity; behavior bisphenol A; endocrine disruptor; reproduction; epigenetics; toxicity; behavior
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mileva, G.; Baker, S.L.; Konkle, A.T.; Bielajew, C. Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior. Int. J. Environ. Res. Public Health 2014, 11, 7537-7561.

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