Mar. Drugs 2011, 9(9), 1440-1468; doi:10.3390/md9091440

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

1,* email, 2email and 1email
Received: 28 July 2011; in revised form: 11 August 2011 / Accepted: 15 August 2011 / Published: 25 August 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to produce bioactive secondary metabolites and studies have been limited to only a few species. Most of the compounds isolated from vibrios so far are non-ribosomal peptides or hybrids thereof, with examples of N-containing compounds produced independent of nonribosomal peptide synthetases (NRPS). Though covering a limited chemical space, vibrios produce compounds with attractive biological activities, including antibacterial, anticancer, and antivirulence activities. This review highlights some of the most interesting structures from this group of bacteria. Many compounds found in vibrios have also been isolated from other distantly related bacteria. This cosmopolitan occurrence of metabolites indicates a high incidence of horizontal gene transfer, which raises interesting questions concerning the ecological function of some of these molecules. This account underlines the pending potential for exploring new bacterial sources of bioactive compounds and the challenges related to their investigation.
Keywords: Vibrio; marine bacteria; bioactive; antibiotics; siderophores
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MDPI and ACS Style

Mansson, M.; Gram, L.; Larsen, T.O. Production of Bioactive Secondary Metabolites by Marine Vibrionaceae. Mar. Drugs 2011, 9, 1440-1468.

AMA Style

Mansson M, Gram L, Larsen TO. Production of Bioactive Secondary Metabolites by Marine Vibrionaceae. Marine Drugs. 2011; 9(9):1440-1468.

Chicago/Turabian Style

Mansson, Maria; Gram, Lone; Larsen, Thomas O. 2011. "Production of Bioactive Secondary Metabolites by Marine Vibrionaceae." Mar. Drugs 9, no. 9: 1440-1468.

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