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• Leyton, Y
• Borquez, J
• Darias, J
• Cueto, M
• Díaz-Marrero, A
• Riquelme, C
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• Leyton, Y
• Borquez, J
• Darias, J
• Cueto, M
• Díaz-Marrero, A
• Riquelme, C
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• Leyton, Y
• Borquez, J
• Darias, J
• Cueto, M
• Díaz-Marrero, A
• Riquelme, C

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Mar. Drugs 2011, 9(10), 2155-2163; doi:10.3390/md9102155

Communication

Oleic Acid Produced by a Marine Vibrio spp. Acts as an Anti-Vibrio parahaemolyticus Agent

Yanett Leyton ^1,2,* , Jorge Borquez ³ , José Darias ⁴ , Mercedes Cueto ⁴ , Ana R. Díaz-Marrero ⁴  and Carlos Riquelme ¹

¹ Microbial Ecology Laboratory, Faculty of Marine Resources, Antofagasta University, Antofagasta 1310000, Chile ² Doctorate Applied Science, Mention Coastal Marine Systems, Faculty of Marine Resources, Antofagasta University, Antofagasta 1310000, Chile ³ Laboratory of Natural Products, Department of Chemistry, Antofagasta University, Antofagasta 1310000, Chile ⁴ Institute of Natural Products and Agrobiology, CSIC, La Laguna, Tenerife 38206, Spain

* Author to whom correspondence should be addressed.

Received: 19 July 2011; in revised form: 13 August 2011 / Accepted: 23 August 2011 / Published: 24 October 2011

(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)

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Abstract: It is known that some strains of Vibrio parahaemolyticus are responsible for gastroenteric diseases caused by the ingestion of marine organisms contaminated with these bacterial strains. Organic products that show inhibitory activity on the growth of the pathogenic V. parahaemolyticus were extracted from a Vibrio native in the north of Chile. The inhibitory organic products were isolated by reverse phase chromatography and permeation by Sephadex LH20, and were characterized by spectroscopic and spectrometric techniques. The results showed that the prevailing active product is oleic acid, which was compared with standards by gas chromatography and high-performance liquid chromatography (HPLC). These active products might be useful for controlling the proliferation of pathogenic clones of V. parahaemolyticus.

Keywords: bioactive marine products; inhibition; Vibrio parahaemolyticus; oleic acid

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