Mar. Drugs 2011, 9(8), 1428-1439; doi:10.3390/md9081428
Article

Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299

Sumei Li 1 email, Xinpeng Tian 1 email, Siwen Niu 1 email, Wenjun Zhang 1 email, Yuchan Chen 2 email, Haibo Zhang 1 email, Xianwen Yang 1 email, Weimin Zhang 2 email, Wenjun Li 3 email, Si Zhang 1 email, Jianhua Ju 1 email and Changsheng Zhang 1,* email
1 CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2 Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China 3 Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China
* Author to whom correspondence should be addressed.
Received: 21 July 2011; in revised form: 8 August 2011 / Accepted: 12 August 2011 / Published: 23 August 2011
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Abstract: Pseudonocardians A–C (2–4), three new diazaanthraquinone derivatives, along with a previously synthesized compound deoxynyboquinone (1), were produced by the strain SCSIO 01299, a marine actinomycete member of the genus Pseudonocardia, isolated from deep-sea sediment of the South China Sea. The structures of compounds 1–4 were determined by mass spectrometry and NMR experiments (1H, 13C, HSQC, and HMBC). The structure of compound 1, which was obtained for the first time from a natural source, was confirmed by X-ray analysis. Compounds 1–3 exhibited potent cytotoxic activities against three tumor cell lines of SF-268, MCF-7 and NCI-H460 with IC50 values between 0.01 and 0.21 μm, and also showed antibacterial activities on Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Bacillus thuringensis SCSIO BT01, with MIC values of 1–4 μg mL−1.
Keywords: marine actinomycetes; Pseudonocardia; natural products; cytotoxicity; antibacterial; South China Sea

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Cite This Article

MDPI and ACS Style

Li, S.; Tian, X.; Niu, S.; Zhang, W.; Chen, Y.; Zhang, H.; Yang, X.; Zhang, W.; Li, W.; Zhang, S.; Ju, J.; Zhang, C. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Mar. Drugs 2011, 9, 1428-1439.

AMA Style

Li S, Tian X, Niu S, Zhang W, Chen Y, Zhang H, Yang X, Zhang W, Li W, Zhang S, Ju J, Zhang C. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Marine Drugs. 2011; 9(8):1428-1439.

Chicago/Turabian Style

Li, Sumei; Tian, Xinpeng; Niu, Siwen; Zhang, Wenjun; Chen, Yuchan; Zhang, Haibo; Yang, Xianwen; Zhang, Weimin; Li, Wenjun; Zhang, Si; Ju, Jianhua; Zhang, Changsheng. 2011. "Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299." Mar. Drugs 9, no. 8: 1428-1439.

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