Next Article in Journal
Application of Spectroscopic Methods for Structural Analysis of Chitin and Chitosan
Next Article in Special Issue
In Situ Aquaculture Methods for Dysidea avara (Demospongiae, Porifera) in the Northwestern Mediterranean
Previous Article in Journal
Halogenated Indole Alkaloids from Marine Invertebrates
Previous Article in Special Issue
Marine Drugs from Sponge-Microbe Association—A Review
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2010, 8(5), 1550-1566; doi:10.3390/md8051550

Biological Activities of Aqueous and Organic Extracts from Tropical Marine Sponges

1
Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia
2
Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, 60596 Frankfurt, Germany
*
Author to whom correspondence should be addressed.
Received: 3 March 2010 / Revised: 26 March 2010 / Accepted: 2 April 2010 / Published: 28 April 2010
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
View Full-Text   |   Download PDF [366 KB, uploaded 24 February 2015]

Abstract

We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested for hemolytic, hemagglutinating, antibacterial and anti-acetylcholinesterase (AChE) activities, as well as their ability to inhibit or activate cell protein phosphatase 1 (PP1). The most interesting activities were obtained from extracts of Ircinia felix, Pandaros acanthifolium, Topsentia ophiraphidites, Verongula rigida and Neofibularia nolitangere. Aqueous and organic extracts of I. felix and V. rigida showed strong antibacterial activity. Topsentia aqueous and some organic extracts were strongly hemolytic, as were all organic extracts from I. felix. The strongest hemolytic activity was observed in aqueous extracts from P. acanthifolium. Organic extracts of N. nolitangere and I. felix inhibited PP1. The aqueous extract from Myrmekioderma styx possessed the strongest hemagglutinating activity, whilst AChE inhibiting activity was found only in a few sponges and was generally weak, except in the methanolic extract of T. ophiraphidites.
Keywords: tropical marine sponges; hemolysis; hemagglutination; antibacterial activity; acetylcholinesterase (AChE) inhibition; protein phosphatase 1 (PP1) inhibition/activation tropical marine sponges; hemolysis; hemagglutination; antibacterial activity; acetylcholinesterase (AChE) inhibition; protein phosphatase 1 (PP1) inhibition/activation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sepčić, K.; Kauferstein, S.; Mebs, D.; Turk, T. Biological Activities of Aqueous and Organic Extracts from Tropical Marine Sponges. Mar. Drugs 2010, 8, 1550-1566.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top