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Mar. Drugs 2010, 8(10), 2569-2577; doi:10.3390/md8102569

Demospongic Acids Revisited

*  and
Groupe Mer, Molécules, Santé MMS/EA 2160, Equipe 7: Lipides marins à activité biologique, Pôle Mer et Littoral, Faculté de Pharmacie, Université de Nantes, France
* Author to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 27 September 2010 / Accepted: 30 September 2010 / Published: 8 October 2010
(This article belongs to the Special Issue Marine Lipids)
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The well-known fatty acids with a D5,9 unsaturation system were designated for a long period as demospongic acids, taking into account that they originally occurred in marine Demospongia sponges. However, such acids have also been observed in various marine sources with a large range of chain-lengths (C16–C32) and from some terrestrial plants with short acyl chains (C18–C19). Finally, the D5,9 fatty acids appear to be a particular type of non-methylene-interrupted fatty acids (NMA FAs). This article reviews the occurrence of these particular fatty acids in marine and terrestrial organisms and shows the biosynthetic connections between D5,9 fatty acids and other NMI FAs.
Keywords: demospongic acids; marine lipids; sponges; marine invertebrates; non-methylene interrupted fatty acids demospongic acids; marine lipids; sponges; marine invertebrates; non-methylene interrupted fatty acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kornprobst, J.-M.; Barnathan, G. Demospongic Acids Revisited. Mar. Drugs 2010, 8, 2569-2577.

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