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Demospongic Acids Revisited
Mar. Drugs 2010, 8(10), 2597-2604; doi:10.3390/md8102597

Effect of Marine Polyunsaturated Fatty Acids on Biofilm Formation of Candida albicans and Candida dubliniensis

Received: 2 September 2010 / Revised: 27 September 2010 / Accepted: 28 September 2010 / Published: 8 October 2010
(This article belongs to the Special Issue Marine Lipids)
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The effect of marine polyunsaturated fatty acids on biofilm formation by the human pathogens Candida albicans and Candida dubliniensis was investigated. It was found that stearidonic acid (18:4 n-3), eicosapentaenoic acid (20:5 n-3), docosapentaenoic acid (22:5 n-3) and docosahexaenoic acid (22:6 n-3) have an inhibitory effect on mitochondrial metabolism of both C. albicans and C. dubliniensis and that the production of biofilm biomass by C. dubliniensis was more susceptible to these fatty acids than C. albicans. Ultrastructural differences, which may be due to increased oxidative stress, were observed between treated and untreated cells of C. albicans and C. dubliniensis with formation of rough cell walls by both species and fibrillar structures in C. dubliniensis. These results indicate that marine polyunsaturated fatty acids may be useful in the treatment and/or prevention of biofilms formed by these pathogenic yeasts.
Keywords: Candida albicans; Candida dubliniensis; polyunsaturated fatty acids Candida albicans; Candida dubliniensis; polyunsaturated fatty acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thibane, V.S.; Kock, J.L.F.; Ells, R.; Wyk, P.W.J.; Pohl, C.H. Effect of Marine Polyunsaturated Fatty Acids on Biofilm Formation of Candida albicans and Candida dubliniensis. Mar. Drugs 2010, 8, 2597-2604.

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