Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

doi:10.3390/md7030435

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Mar. Drugs 2009, 7(3), 435-444; doi:10.3390/md7030435

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Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

Sherif S. Ebada ^1,6 , Victor Wray ² , Nicole J. De Voogd ³ , Zhiwei Deng ⁴ , Wenhan Lin ⁵^,* and Peter Proksch ¹^,*

¹ Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany ² Helmholtz Center for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany ³ National Museum of Natural History, PO Box 9517 2300 RA Leiden, The Netherlands ⁴ Analytical and Testing Center, Beijing Normal University, Beijing 100875, China ⁵ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China ⁶ Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Ain-Shams University, Abbasia, Cairo, Egypt

* Authors to whom correspondence should be addressed.

Received: 21 August 2009; in revised form: 2 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009

(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)

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Abstract: Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC₅₀ values of <0.1 μg/mL.

Keywords: Jaspis splendens; jaspamide Q and R; structure elucidation; cytotoxic activity

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MDPI and ACS Style

Ebada, S.S.; Wray, V.; De Voogd, N.J.; Deng, Z.; Lin, W.; Proksch, P. Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens. Mar. Drugs 2009, 7, 435-444.

AMA Style

Ebada S.S., Wray V., De Voogd N.J., Deng Z., Lin W., Proksch P. Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens. Marine Drugs. 2009; 7(3):435-444.

Chicago/Turabian Style

Ebada, Sherif S.; Wray, Victor; De Voogd, Nicole J.; Deng, Zhiwei; Lin, Wenhan; Proksch, Peter. 2009. "Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens." Mar. Drugs 7, no. 3: 435-444.

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