Next Article in Journal
Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
Next Article in Special Issue
Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
Previous Article in Journal
The Influence of Bioactive Oxylipins from Marine Diatoms on Invertebrate Reproduction and Development
Previous Article in Special Issue
Phage Therapy and Photodynamic Therapy: Low Environmental Impact Approaches to Inactivate Microorganisms in Fish Farming Plants
Mar. Drugs 2009, 7(3), 401-434; doi:10.3390/md7030401

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

* , #
Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA # These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 30 July 2009 / Revised: 20 August 2009 / Accepted: 24 August 2009 / Published: 26 August 2009
(This article belongs to the Special Issue Marine Anti-infective Agents)
View Full-Text   |   Download PDF [193 KB, uploaded 24 February 2015]   |  


S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
Keywords: adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Sufrin, J.R.; Finckbeiner, S.; Oliver, C.M. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Mar. Drugs 2009, 7, 401-434.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert