Mar. Drugs 2009, 7(3), 401-434; doi:10.3390/md7030401
Review

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Janice R. Sufrin* email, Steven Finckbeiner # email and Colin M. Oliver # email
Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA # These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 30 July 2009; in revised form: 20 August 2009 / Accepted: 24 August 2009 / Published: 26 August 2009
(This article belongs to the Special Issue Marine Anti-infective Agents)
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Abstract: S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
Keywords: adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing

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Cite This Article

MDPI and ACS Style

Sufrin, J.R.; Finckbeiner, S.; Oliver, C.M. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Mar. Drugs 2009, 7, 401-434.

AMA Style

Sufrin JR, Finckbeiner S, Oliver CM. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Marine Drugs. 2009; 7(3):401-434.

Chicago/Turabian Style

Sufrin, Janice R.; Finckbeiner, Steven; Oliver, Colin M. 2009. "Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives." Mar. Drugs 7, no. 3: 401-434.

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