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Mar. Drugs 2009, 7(3), 401-434; doi:10.3390/md7030401

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA
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These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 30 July 2009 / Revised: 20 August 2009 / Accepted: 24 August 2009 / Published: 26 August 2009
(This article belongs to the Special Issue Marine Anti-infective Agents)
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Abstract

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. View Full-Text
Keywords: adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sufrin, J.R.; Finckbeiner, S.; Oliver, C.M. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Mar. Drugs 2009, 7, 401-434.

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