Next Article in Journal
Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
Next Article in Special Issue
Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
Previous Article in Journal
The Influence of Bioactive Oxylipins from Marine Diatoms on Invertebrate Reproduction and Development
Previous Article in Special Issue
Phage Therapy and Photodynamic Therapy: Low Environmental Impact Approaches to Inactivate Microorganisms in Fish Farming Plants
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2009, 7(3), 401-434;

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 30 July 2009 / Revised: 20 August 2009 / Accepted: 24 August 2009 / Published: 26 August 2009
(This article belongs to the Special Issue Marine Anti-infective Agents)
View Full-Text   |   Download PDF [193 KB, uploaded 24 February 2015]


S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. View Full-Text
Keywords: adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Sufrin, J.R.; Finckbeiner, S.; Oliver, C.M. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Mar. Drugs 2009, 7, 401-434.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top