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Mar. Drugs 2009, 7(3), 401-434; doi:10.3390/md7030401

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

* , #
Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA # These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 30 July 2009 / Revised: 20 August 2009 / Accepted: 24 August 2009 / Published: 26 August 2009
(This article belongs to the Special Issue Marine Anti-infective Agents)
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S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
Keywords: adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing adenosylmethionine; ethylene; polyamines; radical SAM; quorum sensing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sufrin, J.R.; Finckbeiner, S.; Oliver, C.M. Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives. Mar. Drugs 2009, 7, 401-434.

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