Mar. Drugs 2009, 7(3), 445-450; doi:10.3390/md7030445
Article

1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.

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Received: 31 August 2009; in revised form: 7 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines.
Keywords: marine sponges; alkaloids; cytotoxicity; Mycale sp.
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MDPI and ACS Style

Coello, L.; Martín, M.J.; Reyes, F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Mar. Drugs 2009, 7, 445-450.

AMA Style

Coello L, Martín MJ, Reyes F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Marine Drugs. 2009; 7(3):445-450.

Chicago/Turabian Style

Coello, Laura; Martín, María J.; Reyes, Fernando. 2009. "1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.." Mar. Drugs 7, no. 3: 445-450.

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