Next Article in Journal
Phase II Study of Biweekly Plitidepsin as Second-Line Therapy for Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium
Next Article in Special Issue
A New Polyunsaturated Brominated Fatty Acid from a Haliclona Sponge
Previous Article in Journal / Special Issue
Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2009, 7(3), 445-450; doi:10.3390/md7030445

1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.

Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain
*
Author to whom correspondence should be addressed.
Received: 31 August 2009 / Revised: 7 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
View Full-Text   |   Download PDF [92 KB, uploaded 24 February 2015]   |  

Abstract

A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines. View Full-Text
Keywords: marine sponges; alkaloids; cytotoxicity; Mycale sp. marine sponges; alkaloids; cytotoxicity; Mycale sp.
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Coello, L.; Martín, M.J.; Reyes, F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Mar. Drugs 2009, 7, 445-450.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top