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Mar. Drugs 2009, 7(3), 445-450; doi:10.3390/md7030445

1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.

Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain
* Author to whom correspondence should be addressed.
Received: 31 August 2009 / Revised: 7 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines.
Keywords: marine sponges; alkaloids; cytotoxicity; Mycale sp. marine sponges; alkaloids; cytotoxicity; Mycale sp.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Coello, L.; Martín, M.J.; Reyes, F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Mar. Drugs 2009, 7, 445-450.

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