1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.

doi:10.3390/md7030445

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Mar. Drugs 2009, 7(3), 445-450; doi:10.3390/md7030445

Article

1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.

Laura Coello, María Jesús Martín and Fernando Reyes*

Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain

* Author to whom correspondence should be addressed.

Received: 31 August 2009; in revised form: 7 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009

(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)

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Abstract: A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines.

Keywords: marine sponges; alkaloids; cytotoxicity; Mycale sp.

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Cite This Article

MDPI and ACS Style

Coello, L.; Martín, M.J.; Reyes, F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Mar. Drugs 2009, 7, 445-450.

AMA Style

Coello L, Martín MJ, Reyes F. 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.. Marine Drugs. 2009; 7(3):445-450.

Chicago/Turabian Style

Coello, Laura; Martín, María J.; Reyes, Fernando. 2009. "1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.." Mar. Drugs 7, no. 3: 445-450.

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