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Mar. Drugs 2009, 7(3), 435-444; doi:10.3390/md7030435
Article

Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

1,6
, 2
, 3
, 4
, 5,*  and 1,*
Received: 21 August 2009; in revised form: 2 September 2009 / Accepted: 14 September 2009 / Published: 15 September 2009
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract: Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC50 values of <0.1 μg/mL.
Keywords: Jaspis splendens; jaspamide Q and R; structure elucidation; cytotoxic activity Jaspis splendens; jaspamide Q and R; structure elucidation; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ebada, S.S.; Wray, V.; De Voogd, N.J.; Deng, Z.; Lin, W.; Proksch, P. Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens. Mar. Drugs 2009, 7, 435-444.

AMA Style

Ebada SS, Wray V, De Voogd NJ, Deng Z, Lin W, Proksch P. Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens. Marine Drugs. 2009; 7(3):435-444.

Chicago/Turabian Style

Ebada, Sherif S.; Wray, Victor; De Voogd, Nicole J.; Deng, Zhiwei; Lin, Wenhan; Proksch, Peter. 2009. "Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens." Mar. Drugs 7, no. 3: 435-444.



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