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Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs Platz 3, 97082 Würzburg, Germany
Research Center for Infectious Diseases, Josef-Schneider-Straße 2, 97080 Würzburg, Germany
Department of Medicinal Chemistry, University of Utah, Salt Lake City, 84112 Utah, USA
Present address: School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
* Author to whom correspondence should be addressed.
Received: 26 December 2009; in revised form: 2 February 2010 / Accepted: 4 February 2010 / Published: 23 February 2010
Abstract: Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC50 < 0.11 µM; staurosporine IC50 5.30 µM) and Trypanosoma brucei brucei (valinomycin IC50 0.0032 µM; staurosporine IC50 0.022 µM; butenolide IC50 31.77 µM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities.
Keywords: marine sponges; Streptomyces; valinomycin; staurosporine; butenolide; anti-parasitic
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Pimentel-Elardo, S.M.; Kozytska, S.; Bugni, T.S.; Ireland, C.M.; Moll, H.; Hentschel, U. Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges. Mar. Drugs 2010, 8, 373-380.
Pimentel-Elardo SM, Kozytska S, Bugni TS, Ireland CM, Moll H, Hentschel U. Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges. Marine Drugs. 2010; 8(2):373-380.
Pimentel-Elardo, Sheila Marie; Kozytska, Svitlana; Bugni, Tim S.; Ireland, Chris M.; Moll, Heidrun; Hentschel, Ute. 2010. "Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges." Mar. Drugs 8, no. 2: 373-380.