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Mar. Drugs 2016, 14(8), 139; doi:10.3390/md14080139

The Role of Spongia sp. in the Discovery of Marine Lead Compounds

1
LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
2
Sea4Us—Biotecnologia de Recursos Marinhos, Ltd., 8650-378 Sagres, Portugal
3
Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 16 June 2016 / Revised: 6 July 2016 / Accepted: 8 July 2016 / Published: 23 July 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)

Abstract

A comprehensive review on the chemistry of Spongia sp. is here presented, together with the biological activity of the isolated compounds. The compounds are grouped in sesquiterpene quinones, diterpenes, C21 and other linear furanoterpenes, sesterterpenes, sterols (including secosterols), macrolides and miscellaneous compounds. Among other reports we include studies on the intraspecific diversity of a Mediterranean species, compounds isolated from associated sponge and nudibranch and compounds isolated from S. zimocca and the red seaweed Laurentia microcladia. Under biological activity a table of the reported biological activities of the various compounds and the biological screening of extracts are described. The present review covers the literature from 1971 to 2015. View Full-Text
Keywords: Spongia sp.; sesquiterpene quinones; diterpenes; C21 furanoterpenes; sesterterpenes; sterols; macrolides; biological activity Spongia sp.; sesquiterpene quinones; diterpenes; C21 furanoterpenes; sesterterpenes; sterols; macrolides; biological activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Máximo, P.; Ferreira, L.M.; Branco, P.; Lima, P.; Lourenço, A. The Role of Spongia sp. in the Discovery of Marine Lead Compounds. Mar. Drugs 2016, 14, 139.

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