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Mar. Drugs 2016, 14(8), 146; doi:10.3390/md14080146

Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.

1,2,†
,
1,†
,
1
and
1,*
1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, 196#, Huayang West Street, Yangzhou 225127, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 14 June 2016 / Revised: 16 July 2016 / Accepted: 26 July 2016 / Published: 1 August 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [1716 KB, uploaded 1 August 2016]   |  

Abstract

Three new polyhydroxylated sterol derivatives topsensterols A–C (13) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (l3) possess novel 2β,3α,4β,6α-tetrahydroxy-14α-methyl Δ9(11) steroidal nuclei with unusual side chains. Compound 2 exhibited cytotoxicity against human gastric carcinoma cell line SGC-7901 with an IC50 value of 8.0 μM. Compound 3 displayed cytotoxicity against human erythroleukemia cell line K562 with an IC50 value of 6.0 μM. View Full-Text
Keywords: marine sponge; Topsentia sp.; polyhydroxylated sterol; topsensterol; cytotoxicity marine sponge; Topsentia sp.; polyhydroxylated sterol; topsensterol; cytotoxicity
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MDPI and ACS Style

Chen, M.; Wu, X.-D.; Zhao, Q.; Wang, C.-Y. Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.. Mar. Drugs 2016, 14, 146.

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