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Mar. Drugs 2015, 13(5), 3154-3181; doi:10.3390/md13053154

Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates

1
Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt
2
National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt
3
Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st. (former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt
4
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Received: 9 April 2015 / Revised: 5 May 2015 / Accepted: 7 May 2015 / Published: 20 May 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [1162 KB, uploaded 20 May 2015]   |  

Abstract

Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species. View Full-Text
Keywords: terpenes; Red Sea; marine ecosystem; marine invertebrates; biomedical leads terpenes; Red Sea; marine ecosystem; marine invertebrates; biomedical leads
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hegazy, M.E.F.; Mohamed, T.A.; Alhammady, M.A.; Shaheen, A.M.; Reda, E.H.; Elshamy, A.I.; Aziz, M.; Paré, P.W. Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates. Mar. Drugs 2015, 13, 3154-3181.

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