Next Article in Journal
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice
Next Article in Special Issue
Sulfated Galactan from Palisada flagellifera Inhibits Toxic Effects of Lachesis muta Snake Venom
Previous Article in Journal
Seaweed Hydrocolloid Production: An Update on Enzyme Assisted Extraction and Modification Technologies
Previous Article in Special Issue
Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(6), 3360-3367; doi:10.3390/md13063360

Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A

1,2,3
,
1,2
,
1,2
,
1,2,* and 1,2
1
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
2
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
3
University of Chinese Academy of Sciences, Yuquanlu 19A, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 18 April 2015 / Accepted: 20 May 2015 / Published: 27 May 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [306 KB, uploaded 27 May 2015]   |  

Abstract

Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1′ diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines. View Full-Text
Keywords: 13-hydroxyl penicilliumin A; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis; cytotoxicity 13-hydroxyl penicilliumin A; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fu, Y.; Wu, P.; Xue, J.; Li, H.; Wei, X. Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A. Mar. Drugs 2015, 13, 3360-3367.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top