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Mar. Drugs 2015, 13(5), 3182-3230; doi:10.3390/md13053182

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

1
REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal
2
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia 30100, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Alejandro M. Mayer
Received: 20 April 2015 / Revised: 1 May 2015 / Accepted: 6 May 2015 / Published: 21 May 2015
View Full-Text   |   Download PDF [424 KB, uploaded 22 May 2015]

Abstract

Marine ecosystems cover more than 70% of the globe’s surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered. View Full-Text
Keywords: marine compounds; enzyme-assisted extraction; ionic liquids; microwave-assisted extraction; pressurized solvent extraction; pulsed electric field-assisted extraction; supercritical fluid extraction; ultrasound-assisted extraction; switchable solvents marine compounds; enzyme-assisted extraction; ionic liquids; microwave-assisted extraction; pressurized solvent extraction; pulsed electric field-assisted extraction; supercritical fluid extraction; ultrasound-assisted extraction; switchable solvents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Grosso, C.; Valentão, P.; Ferreres, F.; Andrade, P.B. Alternative and Efficient Extraction Methods for Marine-Derived Compounds. Mar. Drugs 2015, 13, 3182-3230.

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