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Mar. Drugs 2015, 13(5), 3072-3090; doi:10.3390/md13053072

Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats

1
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
2
College of Earth Science, University of the Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 21 February 2015 / Revised: 8 April 2015 / Accepted: 4 May 2015 / Published: 15 May 2015
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that –OSO3 at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S. View Full-Text
Keywords: differently regioselective chitosan sulfates; hypoglycemic activity; glucose tolerance; plasma insulin; alloxan-induced diabetic rats differently regioselective chitosan sulfates; hypoglycemic activity; glucose tolerance; plasma insulin; alloxan-induced diabetic rats
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xing, R.; He, X.; Liu, S.; Yu, H.; Qin, Y.; Chen, X.; Li, K.; Li, R.; Li, P. Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats. Mar. Drugs 2015, 13, 3072-3090.

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