Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B
AbstractChemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek’s medium led to the isolation of four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and (±) 3, and (R)-3-demethylpurpurester A (4), together with the known purpurester B (5) and pestaphthalides A (6). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of Compound 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra, and that of Compound 4 was revealed by comparing its optical rotation data and CD with those of the literature. The structure of Compound 6 was further confirmed by single-crystal X-ray diffraction experiment using CuKα radiation. All isolated compounds were evaluated for their α-glucosidase inhibitory activities, and Compound 1 showed significant inhibitory activity with IC50 value of 9.05 ± 0.60 μM. Kinetic analysis showed that Compound 1 was a noncompetitive inhibitor of α-glucosidase. Compounds 2 and 6 exhibited moderate inhibitory activities. View Full-Text
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Liu, Y.; Chen, S.; Liu, Z.; Lu, Y.; Xia, G.; Liu, H.; He, L.; She, Z. Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B. Mar. Drugs 2015, 13, 3091-3102.
Liu Y, Chen S, Liu Z, Lu Y, Xia G, Liu H, He L, She Z. Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B. Marine Drugs. 2015; 13(5):3091-3102.Chicago/Turabian Style
Liu, Yayue; Chen, Senhua; Liu, Zhaoming; Lu, Yongjun; Xia, Guoping; Liu, Hongju; He, Lei; She, Zhigang. 2015. "Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B." Mar. Drugs 13, no. 5: 3091-3102.