Mar. Drugs 2014, 12(4), 2326-2340; doi:10.3390/md12042326
Article

A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.

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Received: 30 January 2014; in revised form: 17 March 2014 / Accepted: 28 March 2014 / Published: 22 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 13 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayed significant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancer cell line HCT116.
Keywords: sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid
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MDPI and ACS Style

Kwon, Y.; Kim, S.-H.; Shin, Y.; Bae, M.; Kim, B.-Y.; Lee, S.K.; Oh, K.-B.; Shin, J.; Oh, D.-C. A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.. Mar. Drugs 2014, 12, 2326-2340.

AMA Style

Kwon Y, Kim S-H, Shin Y, Bae M, Kim B-Y, Lee SK, Oh K-B, Shin J, Oh D-C. A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.. Marine Drugs. 2014; 12(4):2326-2340.

Chicago/Turabian Style

Kwon, Yun; Kim, Seong-Hwan; Shin, Yoonho; Bae, Munhyung; Kim, Byung-Yong; Lee, Sang K.; Oh, Ki-Bong; Shin, Jongheon; Oh, Dong-Chan. 2014. "A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.." Mar. Drugs 12, no. 4: 2326-2340.

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