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Mar. Drugs 2014, 12(4), 2156-2163; doi:10.3390/md12042156
Article

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

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Received: 7 February 2014; in revised form: 7 March 2014 / Accepted: 10 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract: Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.
Keywords: deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yan, X.; Tang, X.-X.; Chen, L.; Yi, Z.-W.; Fang, M.-J.; Wu, Z.; Qiu, Y.-K. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Mar. Drugs 2014, 12, 2156-2163.

AMA Style

Yan X, Tang X-X, Chen L, Yi Z-W, Fang M-J, Wu Z, Qiu Y-K. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Marine Drugs. 2014; 12(4):2156-2163.

Chicago/Turabian Style

Yan, Xia; Tang, Xi-Xiang; Chen, Lin; Yi, Zhi-Wei; Fang, Mei-Juan; Wu, Zhen; Qiu, Ying-Kun. 2014. "Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone." Mar. Drugs 12, no. 4: 2156-2163.


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