Next Article in Journal
Briarane Diterpenoids Isolated from Gorgonian Corals between 2011 and 2013
Next Article in Special Issue
A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.
Previous Article in Journal
Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
Previous Article in Special Issue
Molecular Response to Toxic Diatom-Derived Aldehydes in the Sea Urchin Paracentrotus lividus
Mar. Drugs 2014, 12(4), 2156-2163; doi:10.3390/md12042156
Article

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

1,†
,
2,†
,
1
,
2
,
1
,
1,*  and 1,*
1 Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China 2 Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China These authors contribute equally to this work.
* Authors to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 7 March 2014 / Accepted: 10 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
View Full-Text   |   Download PDF [555 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.
Keywords: deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Yan, X.; Tang, X.-X.; Chen, L.; Yi, Z.-W.; Fang, M.-J.; Wu, Z.; Qiu, Y.-K. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Mar. Drugs 2014, 12, 2156-2163.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert