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Mar. Drugs 2014, 12(4), 1757-1772; doi:10.3390/md12041757
Article

Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues

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Received: 7 January 2014; in revised form: 6 February 2014 / Accepted: 27 February 2014 / Published: 27 March 2014
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Abstract: Caulerpin (1a), a bis-indole alkaloid from the marine algal Caulerpa sp., was synthesized in three reaction steps with an overall yield of 11%. The caulerpin analogues (1b1g) were prepared using the same synthetic pathway with overall yields between 3% and 8%. The key reaction involved a radical oxidative aromatic substitution involving xanthate (3) and 3-formylindole compounds (4a4g). All bis-indole compounds synthesized were evaluated against the Mycobacterium tuberculosis strain H37Rv, and 1a was found to display excellent activity (IC50 0.24 µM).
Keywords: synthesis; caulerpin; analogues; anti-tuberculosis activity synthesis; caulerpin; analogues; anti-tuberculosis activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chay, C.I.C.; Cansino, R.G.; Pinzón, C.I.E.; Torres-Ochoa, R.O.; Martínez, R. Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues. Mar. Drugs 2014, 12, 1757-1772.

AMA Style

Chay CIC, Cansino RG, Pinzón CIE, Torres-Ochoa RO, Martínez R. Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues. Marine Drugs. 2014; 12(4):1757-1772.

Chicago/Turabian Style

Chay, Cristina I.C.; Cansino, Rocío G.; Pinzón, Clara I.E.; Torres-Ochoa, Rubén O.; Martínez, Roberto. 2014. "Synthesis and Anti-Tuberculosis Activity of the Marine Natural Product Caulerpin and Its Analogues." Mar. Drugs 12, no. 4: 1757-1772.



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