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Mar. Drugs 2014, 12(3), 1569-1579; doi:10.3390/md12031569
Communication

Ochracenoids A and B, Guaiazulene-Based Analogues from Gorgonian Anthogorgia ochracea Collected from the South China Sea

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Received: 24 December 2013 / Revised: 15 January 2014 / Accepted: 6 February 2014 / Published: 14 March 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract

Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (36), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined as 3R by the comparison of TDDFT calculated electronic circular dichroism with its experimental spectrum. Compound 1 is a rare guaiazulene-based analogue possessing a unique C16 skeleton. The possible generation process of 1 through an intermolecular one-carbon-transfer reaction was also discussed. Compound 2 was previously described as a presumed intermediate involved in the biogenesis of anthogorgienes A and I. Compound 3 exhibited antiproliferative effects on the embryo development of zebrafish Danio rerio.
Keywords: gorgonian; Anthogorgia ochracea; guaiazulene-based analogue; antiproliferative effect; zebrafish embryo gorgonian; Anthogorgia ochracea; guaiazulene-based analogue; antiproliferative effect; zebrafish embryo
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zheng, J.-J.; Shao, C.-L.; Chen, M.; Gan, L.-S.; Fang, Y.-C.; Wang, X.-H.; Wang, C.-Y. Ochracenoids A and B, Guaiazulene-Based Analogues from Gorgonian Anthogorgia ochracea Collected from the South China Sea. Mar. Drugs 2014, 12, 1569-1579.

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