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Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Asia Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 12 November 2013; in revised form: 13 December 2013 / Accepted: 17 January 2014 / Published: 28 January 2014
Abstract: New cembranoids, sarcocrassocolides P–R (1–3) and four known compounds (4–7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3–5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1–7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
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Lin, W.-Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Sung, P.-J.; Su, J.-H.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2014, 12, 840-850.
Lin W-Y, Chen B-W, Huang C-Y, Wen Z-H, Sung P-J, Su J-H, Dai C-F, Sheu J-H. Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Marine Drugs. 2014; 12(2):840-850.
Lin, Wan-Yu; Chen, Bo-Wei; Huang, Chiung-Yao; Wen, Zhi-Hong; Sung, Ping-Jyun; Su, Jui-Hsin; Dai, Chang-Feng; Sheu, Jyh-Horng. 2014. "Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule." Mar. Drugs 12, no. 2: 840-850.