Mar. Drugs 2014, 12(2), 840-850; doi:10.3390/md12020840
Article

Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

1,†email, 1,†email, 1email, 1email, 2,3email, 2,3email, 4email and 1,5,6,7,8,* email
Received: 12 November 2013; in revised form: 13 December 2013 / Accepted: 17 January 2014 / Published: 28 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: New cembranoids, sarcocrassocolides P–R (13) and four known compounds (47) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 35 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 17 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
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MDPI and ACS Style

Lin, W.-Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Sung, P.-J.; Su, J.-H.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2014, 12, 840-850.

AMA Style

Lin W-Y, Chen B-W, Huang C-Y, Wen Z-H, Sung P-J, Su J-H, Dai C-F, Sheu J-H. Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Marine Drugs. 2014; 12(2):840-850.

Chicago/Turabian Style

Lin, Wan-Yu; Chen, Bo-Wei; Huang, Chiung-Yao; Wen, Zhi-Hong; Sung, Ping-Jyun; Su, Jui-Hsin; Dai, Chang-Feng; Sheu, Jyh-Horng. 2014. "Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule." Mar. Drugs 12, no. 2: 840-850.

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