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Mar. Drugs 2014, 12(2), 840-850; doi:10.3390/md12020840
Article

Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

1,†
, 1,†
, 1
, 1
, 2,3
, 2,3
, 4
 and 1,5,6,7,8,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan 7 Asia Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 8 Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 13 December 2013 / Accepted: 17 January 2014 / Published: 28 January 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract

New cembranoids, sarcocrassocolides P–R (13) and four known compounds (47) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 35 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 17 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lin, W.-Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Sung, P.-J.; Su, J.-H.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2014, 12, 840-850.

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