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Mar. Drugs 2014, 12(3), 1471-1494; doi:10.3390/md12031471
Review

The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish

1
,
2
 and
1,3,*
1 Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea 2 Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea 3 Department of Biotechnology, Chosun University, Gwangju 501-759, Korea
* Author to whom correspondence should be addressed.
Received: 10 February 2014 / Revised: 3 March 2014 / Accepted: 3 March 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Marine Lipopolysaccharides)
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Abstract

Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.
Keywords: anti-lipopolysaccharide factor; LPS-binding domain; antimicrobial peptide; marine fish; innate immunity anti-lipopolysaccharide factor; LPS-binding domain; antimicrobial peptide; marine fish; innate immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gopal, R.; Seo, C.H.; Park, Y. The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish. Mar. Drugs 2014, 12, 1471-1494.

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