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Mar. Drugs 2014, 12(12), 6014-6027; doi:10.3390/md12126014

Nano- and Microdelivery Systems for Marine Bioactive Lipids

REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
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Received: 11 October 2014 / Revised: 24 November 2014 / Accepted: 28 November 2014 / Published: 17 December 2014
(This article belongs to the Special Issue Marine Functional Food Products - Cardiovascular Diseases)
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Abstract

There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include ω-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their pharmacokinetics. Thus, the bioavailability of these compounds may be affected, resulting in their inability to reach the target sites at effective concentrations. In this regard, micro/nanoparticles can offer a wide range of solutions that can prevent the degradation of targeted molecules, increase their absorption, uptake and bioavailability. In this work we will present the options currently available concerning micro- and nanodelivery systems for marine lipids; with emphasis on micro/nanoparticles; such as micro/nanocapsules and emulsions. A wide range of bottom-up approaches using casein, chitosan, cyclodextrins, among others; will be discussed. View Full-Text
Keywords: fatty acids; ω-3; liposomes; microparticles; nanoparticles; EPA; DHA fatty acids; ω-3; liposomes; microparticles; nanoparticles; EPA; DHA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pereira, D.M.; Valentão, P.; Andrade, P.B. Nano- and Microdelivery Systems for Marine Bioactive Lipids. Mar. Drugs 2014, 12, 6014-6027.

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