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Mar. Drugs 2014, 12(12), 6014-6027;

Nano- and Microdelivery Systems for Marine Bioactive Lipids

REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
Author to whom correspondence should be addressed.
Received: 11 October 2014 / Revised: 24 November 2014 / Accepted: 28 November 2014 / Published: 17 December 2014
(This article belongs to the Special Issue Marine Functional Food Products - Cardiovascular Diseases)
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There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include ω-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their pharmacokinetics. Thus, the bioavailability of these compounds may be affected, resulting in their inability to reach the target sites at effective concentrations. In this regard, micro/nanoparticles can offer a wide range of solutions that can prevent the degradation of targeted molecules, increase their absorption, uptake and bioavailability. In this work we will present the options currently available concerning micro- and nanodelivery systems for marine lipids; with emphasis on micro/nanoparticles; such as micro/nanocapsules and emulsions. A wide range of bottom-up approaches using casein, chitosan, cyclodextrins, among others; will be discussed. View Full-Text
Keywords: fatty acids; ω-3; liposomes; microparticles; nanoparticles; EPA; DHA fatty acids; ω-3; liposomes; microparticles; nanoparticles; EPA; DHA

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Pereira, D.M.; Valentão, P.; Andrade, P.B. Nano- and Microdelivery Systems for Marine Bioactive Lipids. Mar. Drugs 2014, 12, 6014-6027.

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