Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
Abstract
:1. Introduction
2. Results and Discussion
# | 13C | 1H | 1H–1H COSY | HMBC (H→C) |
---|---|---|---|---|
1 | 133.0 (qC) b | |||
2 | 84.4 (CH) | 5.42 m | H-3, H-16, H-17 | |
3 | 126.0 (CH) | 5.09 br·d (9.2, 0.8) c | H-2, H-18 | C-5, C-18 |
4 | 138.2 (qC) | |||
5 | 35.8 (CH2) | 2.04 m | H-6 | |
6 | 27.6 (CH2) | a: 1.94 m | H-5, H-7 | |
7 | 75.9 (CH) | 5.01 dd (10.4, 2.4) | H-6 | C-8, C-9, 7-OAc |
8 | 82.6 (qC) | |||
9 | 29.9 (CH2) | a: 2.22 m | H-10 | C-10, C-11, C-19 |
10 | 28.7 (CH2) | 2.61 m | H-9 | C-8, C-9, C-11 |
11 | 176.2 (qC) | |||
12 | 68.0 (CH) | 3.76 m | H-13, H-20 | |
13 | 37.5 (CH2) | 1.49 m | H-12, H-14 | C-1, C-14, C-20 |
14 | 21.1 (CH2) | a: 2.24 m | H-13 | C-1, C-2, C-13 |
15 | 128.4 (qC) | |||
16 | 78.1 (CH2) | a: 4.54 dd (11.6, 5.6) | H-2, H-17 | C-1 |
17 | 10.0 (CH3) | 1.66 s | H-2, H-16 | C-1, C-15, C-16 |
18 | 16.4 (CH3) | 1.76 s | H-3 | C-3, C-4, C-5 |
19 | 22.5 (CH3) | 1.40 s | C-7, C-8, C-9 | |
20 | 23.3 (CH3) | 1.19 d (6.0) | H-12 | C-12, C-13 |
7-OAc | 20.9 (CH3) | 2.09 s | 7-OAc | |
3. Experimental Section
3.1. General Experimental Procedures
3.2. Animal Material
3.3. Extraction and Isolation
3.4. Preparation of (R)- and (S)-MTPA Esters of Secocrassumol
3.5. Cytotoxicity Assay
3.6. Anti-HCMV Assay
4. Conclusions
Supplementary Files
Supplementary File 1Acknowledgments
Author Contributions
Conflicts of Interest
References
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Cheng, S.-Y.; Wang, S.-K.; Duh, C.-Y. Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum. Mar. Drugs 2014, 12, 6028-6037. https://doi.org/10.3390/md12126028
Cheng S-Y, Wang S-K, Duh C-Y. Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum. Marine Drugs. 2014; 12(12):6028-6037. https://doi.org/10.3390/md12126028
Chicago/Turabian StyleCheng, Shi-Yie, Shang-Kwei Wang, and Chang-Yih Duh. 2014. "Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum" Marine Drugs 12, no. 12: 6028-6037. https://doi.org/10.3390/md12126028