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Insights into the Toxicological Properties of a Low Molecular Weight Fraction from Zoanthus sociatus (Cnidaria)
CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal
PhD Program in Biological Sciences, National Autonomous University of Mexico, Institute of Cellular Physiology, Mexico DF CP04510, Mexico
PhD Program in Biomedical Sciences, National Autonomous University of Mexico, Institute of Cellular Physiology, Mexico DF CP04510, Mexico
Faculty of Biology, University of La Habana, 25 St 455, La Habana CP 10400, Cuba
* Author to whom correspondence should be addressed.
Received: 21 May 2013; in revised form: 13 June 2013 / Accepted: 27 June 2013 / Published: 13 August 2013
Abstract: The phylum Cnidaria is an ancient group of venomous animals, specialized in the production and delivery of toxins. Many species belonging to the class Anthozoa have been studied and their venoms often contain a group of peptides, less than 10 kDa, that act upon ion channels. These peptides and their targets interact with high affinity producing neurotoxic and cardiotoxic effects, and even death, depending on the dose and the administration pathway. Zoanthiniaria is an order of the Subclass Hexacorallia, class Anthozoa, and unlike sea anemone (order Actiniaria), neither its diversity of toxins nor the in vivo effects of the venoms has been exhaustively explored. In this study we assessed some toxicological tests on mice with a low molecular weight fraction obtained by gel filtration in Sephadex G-50 from Zoanthus sociatus crude extract. The gel filtration chromatogram at 280 nm revealed two major peaks, the highest absorbance corresponding to the low molecular weight fraction. The toxicological effects seem to be mostly autonomic and cardiotoxic, causing death in a dose dependent manner with a LD50 of 792 μg/kg. Moreover, at a dose of 600 μg/kg the active fraction accelerated the KCl-induced lethality in mice.
Keywords: biological activity; toxins; Zoanthus sociatus; Anthozoa; Cnidaria; LD50 mice
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Domínguez-Pérez, D.; Diaz-Garcia, C.M.; García-Delgado, N.; Sierra-Gómez, Y.; Castañeda, O.; Antunes, A. Insights into the Toxicological Properties of a Low Molecular Weight Fraction from Zoanthus sociatus (Cnidaria). Mar. Drugs 2013, 11, 2873-2881.
Domínguez-Pérez D, Diaz-Garcia CM, García-Delgado N, Sierra-Gómez Y, Castañeda O, Antunes A. Insights into the Toxicological Properties of a Low Molecular Weight Fraction from Zoanthus sociatus (Cnidaria). Marine Drugs. 2013; 11(8):2873-2881.
Domínguez-Pérez, Dany; Diaz-Garcia, Carlos M.; García-Delgado, Neivys; Sierra-Gómez, Yusvel; Castañeda, Olga; Antunes, Agostinho. 2013. "Insights into the Toxicological Properties of a Low Molecular Weight Fraction from Zoanthus sociatus (Cnidaria)." Mar. Drugs 11, no. 8: 2873-2881.