Next Article in Journal
Insights into the Toxicological Properties of a Low Molecular Weight Fraction from Zoanthus sociatus (Cnidaria)
Next Article in Special Issue
Cyclodextrin Formulation of the Marine Natural Product Pseudopterosin A Uncovers Optimal Pharmacodynamics in Proliferation Studies of Human Umbilical Vein Endothelial Cells
Previous Article in Journal
Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates
Previous Article in Special Issue
Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications
Mar. Drugs 2013, 11(8), 2846-2872; doi:10.3390/md11082846

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

2,*  and 3,*
1 School of Science and Technology, Bangladesh Open University, Board Bazar, Gazipur 1705, Bangladesh 2 Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science & Technology, Ansan, P.O. Box 29, Seoul 425-600, Korea 3 Department of Biotechnology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh
* Authors to whom correspondence should be addressed.
Received: 1 May 2013 / Revised: 12 July 2013 / Accepted: 29 July 2013 / Published: 12 August 2013
(This article belongs to the Special Issue Marine Secondary Metabolites)


Marine Bacillus species produce versatile secondary metabolites including lipopeptides, polypeptides, macrolactones, fatty acids, polyketides, and isocoumarins. These structurally diverse compounds exhibit a wide range of biological activities, such as antimicrobial, anticancer, and antialgal activities. Some marine Bacillus strains can detoxify heavy metals through reduction processes and have the ability to produce carotenoids. The present article reviews the chemistry and biological activities of secondary metabolites from marine isolates. Side by side, the potential for application of these novel natural products from marine Bacillus strains as drugs, pesticides, carotenoids, and tools for the bioremediation of heavy metal toxicity are also discussed.
Keywords: bioactive compounds; macrolactins; detoxification; biosynthesis; carotenoids; biopesticides bioactive compounds; macrolactins; detoxification; biosynthesis; carotenoids; biopesticides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Mondol, M.A.M.; Shin, H.J.; Islam, M.T. Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity. Mar. Drugs 2013, 11, 2846-2872.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert