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Mar. Drugs 2013, 11(8), 2882-2893; doi:10.3390/md11082882
Article

Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.

1
, 2
, 1
, 3
, 1
, 2
, 1
 and 1,*
1 Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea 2 Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea 3 Division of Agricultural Microbiology, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea
* Author to whom correspondence should be addressed.
Received: 1 June 2013 / Revised: 11 July 2013 / Accepted: 17 July 2013 / Published: 13 August 2013
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Abstract

Separacenes A–D (14), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 14 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher’s method. Separacenes A–B (12), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C–D (34) possess a triene moiety between two diol substructures. Separacenes A–D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
Keywords: marine actinomycete; polyene polyol; cytotoxicity; isocitrate lyase marine actinomycete; polyene polyol; cytotoxicity; isocitrate lyase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bae, M.; Kim, H.; Shin, Y.; Kim, B.Y.; Lee, S.K.; Oh, K.-B.; Shin, J.; Oh, D.-C. Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.. Mar. Drugs 2013, 11, 2882-2893.

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