Mar. Drugs 2013, 11(10), 3632-3660; doi:10.3390/md11103632
Review

Antimicrobial Peptides from Marine Proteobacteria

University of Brest, LUBEM EA 3882, SFR 148, Quimper 29000, France
* Author to whom correspondence should be addressed.
Received: 12 July 2013; in revised form: 30 July 2013 / Accepted: 5 August 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
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Abstract: After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR strains are urgently needed. Bacteria hold much promise as a source of unusual bioactive metabolites. However, the potential of marine bacteria, except for Actinomycetes and Cyanobacteria, has been largely underexplored. In the past two decades, the structures of several antimicrobial compounds have been elucidated in marine Proteobacteria. Of these compounds, polyketides (PKs), synthesised by condensation of malonyl-coenzyme A and/or acetyl-coenzyme A, and non-ribosomal peptides (NRPs), obtained through the linkage of (unusual) amino acids, have recently generated particular interest. NRPs are good examples of naturally modified peptides. Here, we review and compile the data on the antimicrobial peptides isolated from marine Proteobacteria, especially NRPs.
Keywords: Proteobacteria; marine; peptide; antimicrobial; antibiotic; antifungal; NRPS

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MDPI and ACS Style

Desriac, F.; Jégou, C.; Balnois, E.; Brillet, B.; Chevalier, P.L.; Fleury, Y. Antimicrobial Peptides from Marine Proteobacteria. Mar. Drugs 2013, 11, 3632-3660.

AMA Style

Desriac F, Jégou C, Balnois E, Brillet B, Chevalier PL, Fleury Y. Antimicrobial Peptides from Marine Proteobacteria. Marine Drugs. 2013; 11(10):3632-3660.

Chicago/Turabian Style

Desriac, Florie; Jégou, Camille; Balnois, Eric; Brillet, Benjamin; Chevalier, Patrick L.; Fleury, Yannick. 2013. "Antimicrobial Peptides from Marine Proteobacteria." Mar. Drugs 11, no. 10: 3632-3660.

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