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Mar. Drugs 2013, 11(10), 3632-3660; doi:10.3390/md11103632
Review

Antimicrobial Peptides from Marine Proteobacteria

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Received: 12 July 2013 / Revised: 30 July 2013 / Accepted: 5 August 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
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Abstract

After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR strains are urgently needed. Bacteria hold much promise as a source of unusual bioactive metabolites. However, the potential of marine bacteria, except for Actinomycetes and Cyanobacteria, has been largely underexplored. In the past two decades, the structures of several antimicrobial compounds have been elucidated in marine Proteobacteria. Of these compounds, polyketides (PKs), synthesised by condensation of malonyl-coenzyme A and/or acetyl-coenzyme A, and non-ribosomal peptides (NRPs), obtained through the linkage of (unusual) amino acids, have recently generated particular interest. NRPs are good examples of naturally modified peptides. Here, we review and compile the data on the antimicrobial peptides isolated from marine Proteobacteria, especially NRPs.
Keywords: Proteobacteria; marine; peptide; antimicrobial; antibiotic; antifungal; NRPS Proteobacteria; marine; peptide; antimicrobial; antibiotic; antifungal; NRPS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Desriac, F.; Jégou, C.; Balnois, E.; Brillet, B.; Chevalier, P.L.; Fleury, Y. Antimicrobial Peptides from Marine Proteobacteria. Mar. Drugs 2013, 11, 3632-3660.

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