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Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D
AbstractThe total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lauric acid was developed utilizing a Brown allylation reaction followed by an oxidative cleavage-oxidation sequence as the key steps. The activity of these natural products, and natural product analogues was also assessed against Mycobacterium tuberculosis in vitro.
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Giltrap, A.M.; Cergol, K.M.; Pang, A.; Britton, W.J.; Payne, R.J. Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Mar. Drugs 2013, 11, 2382-2397.View more citation formats
Giltrap AM, Cergol KM, Pang A, Britton WJ, Payne RJ. Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Marine Drugs. 2013; 11(7):2382-2397.Chicago/Turabian Style
Giltrap, Andrew M.; Cergol, Katie M.; Pang, Angel; Britton, Warwick J.; Payne, Richard J. 2013. "Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D." Mar. Drugs 11, no. 7: 2382-2397.
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