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Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis
Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal-RN 59078-970, Brazil
Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal-RN 59078-970, Brazil
Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo-SP 04044-020, Brazil
* Author to whom correspondence should be addressed.
Received: 3 May 2013; in revised form: 4 June 2013 / Accepted: 17 June 2013 / Published: 2 August 2013
Abstract: Fucan is a term that defines a family of homo- and hetero-polysaccharides containing sulfated l-fucose in its structure. In this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-α). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. In summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.
Keywords: fucan; brown seaweed; pain; analgesic; dictyotales
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Albuquerque, I.R.L.; Cordeiro, S.L.; Gomes, D.L.; Dreyfuss, J.L.; Filgueira, L.G.A.; Leite, E.L.; Nader, H.B.; Rocha, H.A.O. Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis. Mar. Drugs 2013, 11, 2722-2740.
Albuquerque IRL, Cordeiro SL, Gomes DL, Dreyfuss JL, Filgueira LGA, Leite EL, Nader HB, Rocha HAO. Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis. Marine Drugs. 2013; 11(8):2722-2740.
Albuquerque, Ivan R.L.; Cordeiro, Sara L.; Gomes, Dayanne L.; Dreyfuss, Juliana L.; Filgueira, Luciana G.A.; Leite, Edda L.; Nader, Helena B.; Rocha, Hugo A.O. 2013. "Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis." Mar. Drugs 11, no. 8: 2722-2740.