Mar. Drugs 2013, 11(6), 2216-2229; doi:10.3390/md11062216

Marine Compounds with Therapeutic Potential in Gram-Negative Sepsis

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, the Russian Academy of Sciences, pr. 100 let Vladivostoku, 159, Vladivostok 690022, Russia
* Author to whom correspondence should be addressed.
Received: 23 April 2013; in revised form: 24 May 2013 / Accepted: 7 June 2013 / Published: 19 June 2013
PDF Full-text Download PDF Full-Text [426 KB, uploaded 19 June 2013 14:42 CEST]
Abstract: This paper concerns the potential use of compounds, including lipid A, chitosan, and carrageenan, from marine sources as agents for treating endotoxemic complications from Gram-negative infections, such as sepsis and endotoxic shock. Lipid A, which can be isolated from various species of marine bacteria, is a potential antagonist of bacterial endotoxins (lipopolysaccharide (LPSs)). Chitosan is a widespread marine polysaccharide that is derived from chitin, the major component of crustacean shells. The potential of chitosan as an LPS-binding and endotoxin-neutralizing agent is also examined in this paper, including a discussion on the generation of hydrophobic chitosan derivatives to increase the binding affinity of chitosan to LPS. In addition, the ability of carrageenan, which is the polysaccharide of red alga, to decrease the toxicity of LPS is discussed. We also review data obtained using animal models that demonstrate the potency of carrageenan and chitosan as antiendotoxin agents.
Keywords: sepsis; endotoxin; endotoxin antagonists; lipid A; chitosan; carrageenan

Supplementary Files

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Solov'eva, T.; Davydova, V.; Krasikova, I.; Yermak, I. Marine Compounds with Therapeutic Potential in Gram-Negative Sepsis. Mar. Drugs 2013, 11, 2216-2229.

AMA Style

Solov'eva T, Davydova V, Krasikova I, Yermak I. Marine Compounds with Therapeutic Potential in Gram-Negative Sepsis. Marine Drugs. 2013; 11(6):2216-2229.

Chicago/Turabian Style

Solov'eva, Tamara; Davydova, Viktoria; Krasikova, Inna; Yermak, Irina. 2013. "Marine Compounds with Therapeutic Potential in Gram-Negative Sepsis." Mar. Drugs 11, no. 6: 2216-2229.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert