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Mar. Drugs 2013, 11(6), 2230-2238; doi:10.3390/md11062230
Article

Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus

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Received: 14 March 2013 / Revised: 24 May 2013 / Accepted: 27 May 2013 / Published: 21 June 2013
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Abstract

Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (510) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM.
Keywords: sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, M.-H.; Li, X.-M.; Li, C.-S.; Ji, N.-Y.; Wang, B.-G. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus. Mar. Drugs 2013, 11, 2230-2238.

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