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Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Chunhui Road 17, Yantai 264003, China
* Authors to whom correspondence should be addressed.
Received: 14 March 2013; in revised form: 24 May 2013 / Accepted: 27 May 2013 / Published: 21 June 2013
Abstract: Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM.
Keywords: sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality
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Cite This Article
MDPI and ACS Style
Wang, M.-H.; Li, X.-M.; Li, C.-S.; Ji, N.-Y.; Wang, B.-G. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus. Mar. Drugs 2013, 11, 2230-2238.
Wang M-H, Li X-M, Li C-S, Ji N-Y, Wang B-G. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus. Marine Drugs. 2013; 11(6):2230-2238.
Wang, Ming-Hui; Li, Xiao-Ming; Li, Chun-Shun; Ji, Nai-Yun; Wang, Bin-Gui. 2013. "Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus." Mar. Drugs 11, no. 6: 2230-2238.