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Mar. Drugs 2013, 11(4), 1304-1315; doi:10.3390/md11041304
Article

Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi

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Received: 6 February 2013; in revised form: 4 March 2013 / Accepted: 19 March 2013 / Published: 17 April 2013
(This article belongs to the Special Issue Marine Lipids)
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Abstract: The marine sponge, Axinyssa djiferi, collected on mangrove tree roots in Senegal, was investigated for glycolipids. A mixture containing new glycosphingolipids, named axidjiferoside-A, -B and -C, accounted for 0.07% of sponge biomass (dry weight) and for 2.16% of total lipids. It showed a significant antimalarial activity, with a 50% inhibitory concentration (IC50) of 0.53 ± 0.2 μM against a chloroquine-resistant strain of Plasmodium falciparum. They were identified as homologous β-galactopyranosylceramides composed of 2-amino-(6E)-octadec-6-en-1,3,4-triol, and the major one, axidjiferoside-A (around 60%), contained 2-hydroxytetracosanoic acid. Cytotoxicity was studied in vitro on human cancer cell lines (multiple myeloma, colorectal adenocarcinoma, glioblastoma and two lung cancer NSCLC-N6 and A549). Results of this investigation showed that axidjiferosides are of interest, because they proved a good antiplasmodial activity, with only a low cytotoxicity against various human cell lines and no significant antitrypanosomal and antileishmanial activity. Thus, it seems that galactosylceramides with a β anomeric configuration may be suitable in searching for new antimalarial drugs.
Keywords: Axinyssa; marine sponge glycolipids; glycosphingolipids; antimalarial activity; cytotoxicity Axinyssa; marine sponge glycolipids; glycosphingolipids; antimalarial activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Farokhi, F.; Grellier, P.; Clément, M.; Roussakis, C.; Loiseau, P.M.; Genin-Seward, E.; Kornprobst, J.-M.; Barnathan, G.; Wielgosz-Collin, G. Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi. Mar. Drugs 2013, 11, 1304-1315.

AMA Style

Farokhi F, Grellier P, Clément M, Roussakis C, Loiseau PM, Genin-Seward E, Kornprobst J-M, Barnathan G, Wielgosz-Collin G. Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi. Marine Drugs. 2013; 11(4):1304-1315.

Chicago/Turabian Style

Farokhi, Fereshteh; Grellier, Philippe; Clément, Monique; Roussakis, Christos; Loiseau, Philippe M.; Genin-Seward, Emilie; Kornprobst, Jean-Michel; Barnathan, Gilles; Wielgosz-Collin, Gaëtane. 2013. "Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi." Mar. Drugs 11, no. 4: 1304-1315.


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