Next Article in Journal
Immunomodulatory Effect of Marine Cembrane-Type Diterpenoids on Dendritic Cells
Next Article in Special Issue
Interpreting the Possible Ecological Role(s) of Cyanotoxins: Compounds for Competitive Advantage and/or Physiological Aide?
Previous Article in Journal
Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi
Mar. Drugs 2013, 11(4), 1316-1335; doi:10.3390/md11041316
Article

Chemoecological Screening Reveals High Bioactivity in Diverse Culturable Portuguese Marine Cyanobacteria

1,* , 1
, 1
, 2
, 1,2
, 3,4
 and 1,2
Received: 7 January 2013; in revised form: 12 March 2013 / Accepted: 27 March 2013 / Published: 22 April 2013
(This article belongs to the Special Issue Compounds from Cyanobacteria)
View Full-Text   |   Download PDF [1491 KB, updated 23 April 2013; original version uploaded 22 April 2013]   |   Browse Figures
Abstract: Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments culturing is usually required to produce enough biomass for investigations of their chemical constituents. In this work, we cultured a selection of novel and diverse cyanobacteria isolated from the Portuguese coast, and tested their organic extracts in a series of ecologically-relevant bioassays. The majority of the extracts showed activity in at least one of the bioassays, all of which were run in very small scale. Phylogenetically related isolates exhibited different activity profiles, highlighting the value of microdiversity for bioprospection studies. Furthermore, LC-MS analyses of selected active extracts suggested the presence of previously unidentified secondary metabolites. Overall, the screening strategy employed here, in which previously untapped cyanobacterial diversity was combined with multiple bioassays, proved to be a successful strategy and allowed the selection of several strains for further investigations based on their bioactivity profiles.
Keywords: cyanobacteria; chemical ecology; screening; bioactive compounds; secondary metabolites; phylogenetic analysis cyanobacteria; chemical ecology; screening; bioactive compounds; secondary metabolites; phylogenetic analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Leão, P.N.; Ramos, V.; Gonçalves, P.B.; Viana, F.; Lage, O.M.; Gerwick, W.H.; Vasconcelos, V.M. Chemoecological Screening Reveals High Bioactivity in Diverse Culturable Portuguese Marine Cyanobacteria. Mar. Drugs 2013, 11, 1316-1335.

AMA Style

Leão PN, Ramos V, Gonçalves PB, Viana F, Lage OM, Gerwick WH, Vasconcelos VM. Chemoecological Screening Reveals High Bioactivity in Diverse Culturable Portuguese Marine Cyanobacteria. Marine Drugs. 2013; 11(4):1316-1335.

Chicago/Turabian Style

Leão, Pedro N.; Ramos, Vitor; Gonçalves, Patrício B.; Viana, Flávia; Lage, Olga M.; Gerwick, William H.; Vasconcelos, Vitor M. 2013. "Chemoecological Screening Reveals High Bioactivity in Diverse Culturable Portuguese Marine Cyanobacteria." Mar. Drugs 11, no. 4: 1316-1335.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert