Mar. Drugs 2013, 11(12), 4937-4960; doi:10.3390/md11124937

Eight New Peptaibols from Sponge-Associated Trichoderma atroviride

1,2email, 3email, 2email and 1,* email
Received: 24 September 2013; in revised form: 28 October 2013 / Accepted: 11 November 2013 / Published: 11 December 2013
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel.
Keywords: peptaibols; trichorzianines; Trichoderma atroviride; Axinella polypoides; Axinella verrucosa
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MDPI and ACS Style

Panizel, I.; Yarden, O.; Ilan, M.; Carmeli, S. Eight New Peptaibols from Sponge-Associated Trichoderma atroviride. Mar. Drugs 2013, 11, 4937-4960.

AMA Style

Panizel I, Yarden O, Ilan M, Carmeli S. Eight New Peptaibols from Sponge-Associated Trichoderma atroviride. Marine Drugs. 2013; 11(12):4937-4960.

Chicago/Turabian Style

Panizel, Irina; Yarden, Oded; Ilan, Micha; Carmeli, Shmuel. 2013. "Eight New Peptaibols from Sponge-Associated Trichoderma atroviride." Mar. Drugs 11, no. 12: 4937-4960.

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