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Mar. Drugs 2013, 11(12), 4937-4960; doi:10.3390/md11124937
Article

Eight New Peptaibols from Sponge-Associated Trichoderma atroviride

1,2
,
3
,
2
 and
1,*
1 Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel 2 Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel 3 Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
* Author to whom correspondence should be addressed.
Received: 24 September 2013 / Revised: 28 October 2013 / Accepted: 11 November 2013 / Published: 11 December 2013
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel.
Keywords: peptaibols; trichorzianines; Trichoderma atroviride; Axinella polypoides; Axinella verrucosa peptaibols; trichorzianines; Trichoderma atroviride; Axinella polypoides; Axinella verrucosa
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Panizel, I.; Yarden, O.; Ilan, M.; Carmeli, S. Eight New Peptaibols from Sponge-Associated Trichoderma atroviride. Mar. Drugs 2013, 11, 4937-4960.

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