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Mar. Drugs 2013, 11(12), 4961-4972; doi:10.3390/md11124961
Article

New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp.

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1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China 2 Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China 3 Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education and Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, 74 Zhongshan Road II, Guangzhou 510080, China 4 School of Life Sciences and Biomedical Center, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China
* Authors to whom correspondence should be addressed.
Received: 18 October 2013 / Revised: 14 November 2013 / Accepted: 25 November 2013 / Published: 11 December 2013
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Abstract

Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 13 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cyctotoxic activities against tested cancer cell lines (IC50 < 10 μM).
Keywords: Mangrove; Phomopsis sp.; Phomoxanthones; phomolactonexanthones; decetylphomoxanthone C; MTT assay Mangrove; Phomopsis sp.; Phomoxanthones; phomolactonexanthones; decetylphomoxanthone C; MTT assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ding, B.; Yuan, J.; Huang, X.; Wen, W.; Zhu, X.; Liu, Y.; Li, H.; Lu, Y.; He, L.; Tan, H.; She, Z. New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp.. Mar. Drugs 2013, 11, 4961-4972.

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