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Mar. Drugs 2014, 12(1), 300-316; doi:10.3390/md12010300
Article

Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering

1
, 2
 and 1,*
Received: 30 October 2013; in revised form: 30 December 2013 / Accepted: 30 December 2013 / Published: 16 January 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract: Over the last few years, significant research has been conducted in the construction of artificial bone scaffolds. In the present study, different types of polymer scaffolds, such as chitosan-alginate (Chi-Alg) and chitosan-alginate with fucoidan (Chi-Alg-fucoidan), were developed by a freeze-drying method, and each was characterized as a bone graft substitute. The porosity, water uptake and retention ability of the prepared scaffolds showed similar efficacy. The pore size of the Chi-Alg and Chi-Alg-fucoidan scaffolds were measured from scanning electron microscopy and found to be 62–490 and 56–437 µm, respectively. In vitro studies using the MG-63 cell line revealed profound cytocompatibility, increased cell proliferation and enhanced alkaline phosphatase secretion in the Chi-Alg-fucoidan scaffold compared to the Chi-Alg scaffold. Further, protein adsorption and mineralization were about two times greater in the Chi-Alg-fucoidan scaffold than the Chi-Alg scaffold. Hence, we suggest that Chi-Alg-fucoidan will be a promising biomaterial for bone tissue regeneration.
Keywords: chitosan; alginate; fucoidan; bone tissue engineering; biomaterials chitosan; alginate; fucoidan; bone tissue engineering; biomaterials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Venkatesan, J.; Bhatnagar, I.; Kim, S.-K. Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering. Mar. Drugs 2014, 12, 300-316.

AMA Style

Venkatesan J, Bhatnagar I, Kim S-K. Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering. Marine Drugs. 2014; 12(1):300-316.

Chicago/Turabian Style

Venkatesan, Jayachandran; Bhatnagar, Ira; Kim, Se-Kwon. 2014. "Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering." Mar. Drugs 12, no. 1: 300-316.



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