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Pharmaceuticals 2016, 9(3), 50; doi:10.3390/ph9030050

TRP Channels as Therapeutic Targets in Diabetes and Obesity

1
Department of Physiology, School of Medicine, Tulane University, New Orleans, LA 70112, USA
2
Department of Medicine, Endocrinology Section, School of Medicine, Tulane University, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Arpad Szallasi and Susan M. Huang
Received: 3 June 2016 / Revised: 10 August 2016 / Accepted: 11 August 2016 / Published: 17 August 2016
View Full-Text   |   Download PDF [254 KB, uploaded 17 August 2016]

Abstract

During the last three to four decades the prevalence of obesity and diabetes mellitus has greatly increased worldwide, including in the United States. Both the short- and long-term forecasts predict serious consequences for the near future, and encourage the development of solutions for the prevention and management of obesity and diabetes mellitus. Transient receptor potential (TRP) channels were identified in tissues and organs important for the control of whole body metabolism. A variety of TRP channels has been shown to play a role in the regulation of hormone release, energy expenditure, pancreatic function, and neurotransmitter release in control, obese and/or diabetic conditions. Moreover, dietary supplementation of natural ligands of TRP channels has been shown to have potential beneficial effects in obese and diabetic conditions. These findings raised the interest and likelihood for potential drug development. In this mini-review, we discuss possibilities for better management of obesity and diabetes mellitus based on TRP-dependent mechanisms. View Full-Text
Keywords: TRPV1; TRPM; TRPA1; obesity; diabetes mellitus; metabolism; glucose homeostasis TRPV1; TRPM; TRPA1; obesity; diabetes mellitus; metabolism; glucose homeostasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zsombok, A.; Derbenev, A.V. TRP Channels as Therapeutic Targets in Diabetes and Obesity. Pharmaceuticals 2016, 9, 50.

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