Next Article in Journal
The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy
Next Article in Special Issue
Targeting TRPM2 in ROS-Coupled Diseases
Previous Article in Journal
Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled Study
Previous Article in Special Issue
TRP Channels as Therapeutic Targets in Diabetes and Obesity
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2016, 9(3), 52; doi:10.3390/ph9030052

TRPV1: A Target for Rational Drug Design

1
Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122, USA
2
New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Arpad Szallasi and Susan M. Huang
Received: 13 July 2016 / Revised: 12 August 2016 / Accepted: 18 August 2016 / Published: 23 August 2016
View Full-Text   |   Download PDF [1308 KB, uploaded 23 August 2016]   |  

Abstract

Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX). Many compounds have been developed that either activate or inhibit TRPV1, but none of them are in routine clinical practice. This review will discuss the rationale for antagonists and agonists of TRPV1 for pain relief and other conditions, and strategies to develop new, better drugs to target this ion channel, using the newly available high-resolution structures. View Full-Text
Keywords: TRPV1; capsaicin; vanilloid; pain; nociception TRPV1; capsaicin; vanilloid; pain; nociception
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Carnevale, V.; Rohacs, T. TRPV1: A Target for Rational Drug Design. Pharmaceuticals 2016, 9, 52.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top