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Pharmaceuticals 2012, 5(8), 882-889; doi:10.3390/ph5080882
Article

The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity

1,2
, 1,* , 3
, 1
, 4
 and 3
1 School of Chemical Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia 2 Department of Chemistry, University of Lampung, Bandar Lampung 35145, Lampung, Indonesia 3 School of Biological Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia 4 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 2 July 2012 / Revised: 24 July 2012 / Accepted: 3 August 2012 / Published: 23 August 2012
(This article belongs to the Special Issue Antituberculosis Drugs)
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Abstract

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1–3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.
Keywords: isovestitol; medicarpin; sativan; betulinic acid; Sesbania grandiflora; antituberculosis activity; Mycobacterium tuberculosis isovestitol; medicarpin; sativan; betulinic acid; Sesbania grandiflora; antituberculosis activity; Mycobacterium tuberculosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hasan, N.; Osman, H.; Mohamad, S.; Chong, W.K.; Awang, K.; Zahariluddin, A.S.M. The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity. Pharmaceuticals 2012, 5, 882-889.

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