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• Shakya, N
• Garg, G
• Agrawal, B
• Kumar, R
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• Shakya, N
• Garg, G
• Agrawal, B
• Kumar, R
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• Shakya, N
• Garg, G
• Agrawal, B
• Kumar, R

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Pharmaceuticals 2012, 5(7), 690-718; doi:10.3390/ph5070690

Review

Chemotherapeutic Interventions Against Tuberculosis

Neeraj Shakya ¹ , Gaurav Garg ² , Babita Agrawal ³  and Rakesh Kumar ^1,*

¹ Department of Laboratory Medicine and Pathology, 728-Heritage Medical Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2S2, Canada ² Department of Pharmacy, Mangalayatan University, Beswan, Aligarh 202 145, India ³ Department of Surgery, 728-Heritage Medical Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2S2, Canada

* Author to whom correspondence should be addressed.

Received: 15 May 2012; in revised form: 12 June 2012 / Accepted: 21 June 2012 / Published: 28 June 2012

(This article belongs to the Special Issue Antituberculosis Drugs)

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Abstract: Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by serious side effects, drug interactions and long-term administration. This has prompted urgent research efforts in the discovery and development of new anti-tuberculosis agent(s). Several families of compounds are currently being explored for the treatment of tuberculosis. This review article presents an account of the existing chemotherapeutics and highlights the therapeutic potential of emerging molecules that are at different stages of development for the management of tuberculosis disease.

Keywords: tuberculosis chemotherapy; mycobacterium; drug-resistant tuberculosis; emerging TB drugs

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